What is Ametik?

Ametik is used to treat nausea and vomiting related to surgery or caused by stomach flu.

Ametik may also be used for purposes not listed in this medication guide.


An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains.

Ametik® (Ametik injectable) is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.


Ametik® (Ametik injectable) is indicated for the treatment
Ametik® (Ametik injectable) is indicated for the treatment

Use Ametik solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ametik solution is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Ametik solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Ametik solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Ametik solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Ametik solution and you are taking it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ametik solution.


There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form.

Use: Labeled Indications

Nausea/vomiting: Treatment of postoperative nausea and vomiting; treatment of nausea associated with gastroenteritis


Ametik is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with Ametik HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.


Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.


Oral, as hydrochloride:

Ametik: 300 mg

Generic: 300 mg


Intramuscular, as hydrochloride:

Ametik: 100 mg/mL (2 mL)

Ametik: 100 mg/mL (20 mL) [contains phenol]

Dosing: Adult

Nausea/vomiting: Note: Use the lowest effective dosage based on response and tolerability.

IM: 200 mg 3 or 4 times daily

Oral: 300 mg 3 or 4 times daily

Dosing: Geriatric

Refer to adult dosing; reduce the dose or increase the dosing interval and adjust as needed based on patient response.

Dosing: Pediatric

Note: Use in pediatric patients is strongly discouraged due to risk of EPS, serious CNS effects, and other adverse reactions. Expert recommendations for nausea and vomiting management do not suggest Ametik as a therapeutic option; use has been replaced by newer agents with an improved safety profile (MMWR 2003; SAA [Gan 2014]). Although rectal dosing may still be referred to in pediatric textbooks, rectal formulations of Ametik are no longer available.

Parenteral formulations are contraindicated in pediatric patients.

Nausea and vomiting, opioid induced: Limited data available (Kliegman 2016): Children and Adolescents:

<15 kg:

Oral: 100 mg every 6 hours as needed

≥15 kg:

Oral: 200 mg every 6 hours as needed

Ametik may increase the side effects of other drugs that make you sleepy (such as cold medicine, pain medication, muscle relaxants, and medicine for seizures, depression or anxiety). Before using Ametik, tell your doctor if you are using any of these medicines.

There may be other drugs that can affect Ametik. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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